- Scene Investigators
- Scene It? Twilight
- Schacht
- SCHAR: Blue Shield Alliance
- Schein
- Щелкунчик и Крысиный король
- Schizm: Mysterious Journey
- Schizoid
- School 26
- School Bus Fun
- School Girl/Zombie Hunter
- Schoolmates: The Mystery of the Magical Bracelet
- Schools of Magic
- Schrödinger's Cat and the Raiders of the Lost Quark
- Sci-Fantasy Defence
- Sci-Fi Heroes
- SciAnts
- SciBeaver
- Science Girls!
- Scintillatron 4096
- Scivelation
- Scooby Doo! & Looney Tunes Cartoon Universe: Adventure
- Scooby-Doo! and the Spooky Swamp
- Scooby-Doo! First Frights
- Score International Baja 1000
- Scoregasm
- Scorn
- Scorpion Disfigured
- Scotland Yard (2012)
- Scott in Space
- Scott Pilgrim vs. the World: The Game
- Scourge of War: Antietam
- Scourge of War: Brandy Station
- Scourge of War: Chancellorsville
- Scourge of War: Gettysburg
- Scourge of War: Gettysburg 150th Anniversary Collection
- Scourge of War: Pipe Creek
- Scourge of War: Quatre Bras
- Scourge of War: Waterloo
- Scourge: Outbreak
- Scourge Project: Episodes 1 and 2, The
- ScourgeBringer
- SCP-479: Shadows of the Mind
- SCP: Secret Files
- Scrabble Interactive: 2009 Edition
- Scram Kitty and His Buddy on Rails
- Scrap Games
- Scrap Mechanic
- Scrap Metal
- Scrap Squad
- Scrapbook Paige
- Scrapland
- Scrapland Remastered
- Scrapnaut
- Scraps: Modular Vehicle Combat
- Scratches
- Scratches: Director's Cut
- ScreamRide
- Screencheat
- ScrewUp
- Scribble Defense
- Scribble Space
- Scribblenauts
- Scribblenauts Remix
- Scribblenauts Showdown
- Scribblenauts Unlimited
- Scribblenauts Unmasked: A DC Comics Adventure
- Scrolls
- Scrubs
- Scrutinized
- Scuba Diver Adventures: Beyond the Depths
- Scuba Dupa
- SCUM
- Scurvy Scallywags in The Voyage to Discover the Ultimate Sea Shanty
- Scythe: Digital Edition
- SD Gundam Battle Alliance
- SD Gundam G Generation Cross Rays
- Sea Battle VR
- Sea Dogs
- Sea Horizon
- Sea Journey
- Sea Legends
- Sea Legends: Phantasmal Light
- Sea of Craft
- Sea of Solitude
- Sea of Stars
- Sea of Thieves
- Sea Power
- Sea Salt
- Seabeard
- SeaBed
- Seabirds
- SeaCraft
- Seal of Evil
- Seal Team 12
- Seamulator 2009
- SeaOrama: World of Shipping
- Search, The
- Search for Amelia Earhart, The
- Season: A Letter to the Future